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Clin Geriatr Med 38:565591 Trabado S, Al-Salameh A, Croixmarie V, Masson P, Corruble E, Feve B, Colle R, Ripoll L, Walther B, Boursier-Neyret C, Werner E, Becquemont L, Chanson P (2017) The human plasma-metabolome: reference values in 800 french healthy volunteers

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This model involves an initial surge of IL-1 triggered by morphine, followed by an exacerbated release of DAMPs, which in turn increases the activation of TLR4 and the purinergic receptor P2X 7 (P2RX7)