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Bereket A, Lang CH, Blethen SL et al (1995) Effect of insulin on the insulin-like growth factor system in children with new-onset insulin-dependent diabetes mellitus

IGF-1 Elevation Increased growth hormone stimulates the liver to produce more IGF-1 (insulin-like growth factor 1), which mediates many of GH's downstream benefits including muscle growth, tissue repair, and fat metabolism

Long-term effects of chronic GHS-R1a activation on cancer risk (GH and IGF-1 are growth factors), glucose metabolism (GH antagonizes insulin), and joint health are unknown

Prioritising Sleep Research suggests that chronic sleep deprivation can deplete glutathione levels

Precursors like N-acetylcysteine (NAC) can support production but don't restore depleted levels rapidly