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The prodrug 4-chlorokynurenine causes ketamine-like antidepressant effects, but not side effects, by NMDA/glycineB-site inhibition

Statistics by two-sided unpaired t-tests as indicated or compared to untreated cells ( a-c, e ) or ML162 treated cells ( d, f )

These inflammatory mediators cause the intense pelvic pain, adhesion formation, and tissue damage characteristic of the condition

and Johnson, T.L., "Using yeast genetics to study RNA splicing", Methods Mol Biol 1126: 285-298 (2014)

This is where energy production occurs, and a well-functioning system can boost metabolism, helping the body use fat as fuel more effectively