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During early reperfusion, metformin activates AMPK and promotes endothelial nitric oxide synthase (eNOS) phosphorylation at Ser1177(48), effects abolished in AMPK- or eNOS-deficient mice (Zhang et al., 2020)
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Elevated levels of ferritin and transferrin, markers of iron dysregulation, have been observed in clinical ARDS cases, linking iron metabolism to disease severity ( Mitochondrial dysfunction exacerbates iron-driven ferroptosis by impairing the organelles ability to sequester and regulate iron levels
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