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What is more, insulin stimulates PDA cells to secret Shh (sonic hedgehog), IL-6, tissue growth factor (TGF) to promote fibroblast cell growth in TAM (Mutgan et al., 2018)

Sjstedt E, Zhong W, Fagerberg L, et al

The reason for this extension is due to Patent Term Adjustments (PTA) and Patent Term Extensions (PTE) that the law provides for any delay in patent examination at the United States Patent and Trademark Office (USPTO) and regulatory approval by the U.S

This means insulin release occurs only when blood glucose levels are elevated, reducing the risk of hypoglycemia compared to other antidiabetic agents, though this risk increases when used with insulin or sulfonylureas