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Data suggest that activation of GIP-R decreases inflammation in adipose tissue and cytokines levels (such as IL-6) and promotes the rise of serum adiponectin levels, a cytokine with anti-inflammatory effects and beneficial effects on diabetic nephropathy, which can explain potential beneficial effects on kidneys (even if GIP-R are not present) (47)
Our results also could be explained in the light of the study of 68 , who found that LC was able to abolish the toxic effect of ATZ through the improvement of CYP17A1 mRNA and consequently raising of serum testosterone 97
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If that doesnt work, other medications like methotrexate or mycophenolate mofetil can be considered