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This provides a biological basis for considering whether pharmacological GLP-1 therapies, which achieve much higher systemic levels, could also reach the joint and potentially have local effects. Additionally, scientists found that the level of GLP-1 hormone in the synovial fluid is directly tied to the levels in the blood of arthritis patients

Obesity (Silver Spring) 2024;32:472-475

(2020) 158:19992014.e1

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Nausea occurs in approximately 20 to 30 percent of individuals during dose escalation