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Hogan AE, Tobin AM, Ahern T, Corrigan MA, Gaoatswe G, Jackson R, et al

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Apoptosis is a programmed cell death process that eliminates damaged or abnormal cells, including tumor cells ( Modulating immune-related gene expression: Metformin also affects the expression levels of multiple immune-related genes in human cells ( Modulating tumor immune microenvironment Reprogramming: The tumor immune microenvironment determines whether a tumor has benign or malignant biological properties ( In conclusion, metformin regulates the immune response of glioma through various mechanisms, including activating the AMPK signaling pathway, regulating oxidative stress response, affecting the expression of immune-related genes, and tumor immune microenvironment

29 There is no evidence that homocysteine-lowering interventions are beneficial for people with or at risk of CKD