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Takami H et al
Gut 31 (1), 5963
Inhibition of ACSL4 Alleviates Parkinsonism phenotypes by reduction of lipid reactive oxygen species
A 2021 review published in Clinical Pharmacology & Therapeutics noted that most therapeutic peptides undergo proteolytic degradation rather than CYP450-mediated metabolism, making formal hepatic impairment studies less common in peptide drug development [4]
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