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Using in vitro cell-based assays, the researchers found that while both peptides activated the amylin and calcitonin receptors, KBP-336 was more potent and showed a bias towards the calcitonin receptor compared to cagrilintide
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In the following, I compile information on how CoV-2 S and SARS-CoV-2 infection affect elements of the dsDNA-sensing machinery and then develop a worse-case scenario describing hypothetical effects of Spike expression in an innate immune-environment that has already been primed by a prior SARS-CoV-2 infection