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GLP-1 receptor agonists typically increase resting heart rate by 2-4 beats per minute on average, though some patients experience increases of 10 beats per minute or more
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van Bloemendaal L, IJzerman RG, Ten Kulve JS, Barkhof F, Konrad RJ, Drent ML et al (2014)
A 12 week plateau in this phase is normal
After 84 weeks, tirzepatide participants lost an average of 26.6%, while those on the highest dose of retatrutide lost around 24.2% over 48 weeks
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