Semaglutide (Wegovy) : STEP studies found 15% average weight loss after 68 weeks in adults with obesity or overweight (without diabetes) with a weight-related health condition
Physical Fatigue & Sluggishness : Combat daily lethargy by assisting your body's ability to convert stored fats into usable cellular fuel
Other dual agonists include survodutide, mazdutide, and pemvidutide, with evidence of meaningful weight loss and cardiometabolic improvements
This results in: Increased satiety signaling in the brain Slowed gastric emptying Improved insulin sensitivity and post-meal blood sugar regulation Weight loss with semaglutide is driven primarily by appetite regulation and metabolic effects mediated through GLP-1 pathways. Tirzepatide: Dual GIP and GLP-1 Agonist Tirzepatide, the medication in Zepbound, activates two incretin receptors : GLP-1 GIP (glucose-dependent insulinotropic polypeptide) GIP appears to further enhance insulin sensitivity and may amplify appetite regulation when combined with GLP-1
GLP-1 is a class of medications that includes several drugs, such as tirzepatide and Ozempic, designed to help with weight loss by mimicking the natural GLP-1 hormone in the body