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Considering only events within various age groups, the ICERs indicated that SGLT2is were not cost-effective for people aged 1039 years or 4059 years for any intervention (although the ICER for SGLT2is in the secondary prevention population was 29,420), while SGLT2is were cost-effective among people aged 6079 years (ICERs of 28,002 and 328 in the primary prevention and secondary prevention populations, respectively) and 80 years, but GLP-1 RAs were not
The STEP 1 trial (published in the New England Journal of Medicine) documented mean weight reductions of 14.9% with once-weekly semaglutide 2.4 mg compared to 2.4% with placebo, with corresponding improvements in waist circumference of approximately 13.5 cm with semaglutide versus 4.1 cm with placebo after 68 weeks
Research published in obesity journals shows that patients on continuous GLP-1 therapy maintain metabolic advantages that vanish quickly after discontinuation
Why Mounjaro Became Popular for Weight Loss: Although Mounjaro is FDA-approved only for type 2 diabetes, it became widely used off-label for weight loss because: Exceptional Results: Clinical trials showed 15-22% body weight lossbetter than any other weight loss medication available
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