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Additionally, increased cellular uptake of glucose leads to heightened mitochondrial respiration, resulting in elevated ROS production that can further inflammation and cell injury (Li et al., 2015
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Several proteins identified in the EV proteomic analysis overlapped with these modules
For hydrophilic drugs, we optimize encapsulation in the aqueous core, while hydrophobic drugs are integrated into the lipid bilayer
Additionally, NRF2 activators such as bardoxolone methyl may enhance cellular antioxidant defenses, reducing ferroptosis-mediated skin damage
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