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A frequently cited 2019 ikir i et al

Source: 1 Cleveland Clinic GLP-1 Agonists

IGF-1 LR3 must be handled and stored according to established protocols to maintain peptide integrity and ensure consistent research results

Even assuming 100% absorption (which has never been demonstrated for berberine through a patch), you would need to apply over 100 patches simultaneously to match one day of the studied oral dose