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Free radicals can be produced during food metabolization, exercise, and even breathing
This restricts blood flow to and from the heart, which is a primary driver of heart disease
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Indeed, N-acetylgalactosamine-conjugated siRNA targeting AGT was highly effective in suppressing circulating AGT, thereby reducing blood pressure as ACE-inhibitors (ACE-i) and angiotensin-II receptor blockers (ARBs) ( Similarly, a possible SGLT2- i interfering effect on AGT/ANG II system together with intrarenal ANG II/AT2R pathways, especially when combined to RAAS blockers, can be argued
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