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Glycosaminoglycan synthesis also increased by approximately 70%, contributing to improved skin hydration and volume

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the weight in kilograms divided by the square of the height in meters) of 30 or higher, or of 27 or higher with at least one obesity-related complication, and at least one participant-reported unsuccessful dietary effort to lose weight were randomly assigned, in a ratio of 21:3:3:7, to receive for 68 weeks the fixed-dose combination of cagrilintidesemaglutide (2.4 mg of each drug) administered subcutaneously once weekly, semaglutide alone at a dose of 2.4 mg, cagrilintide alone at a dose of 2.4 mg, or placebo, in addition to lifestyle intervention

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