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The amount of homocysteine in the blood is regulated by at least four vitamins: folate, vitamin B 6 , riboflavin, and vitamin B 12 (see Figure 1 )

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The Committee on Publication Ethics (COPE) has published some useful flowcharts to guide researchers who suspect fraud in manuscripts or published articles: Image manipulation in a published article (COPE, 2018a) How to recognise potential authorship problems (COPE, 2018b) Systematic manipulation of the publication process (COPE, 2018c) How to recognise potential manipulation of the peer review process (COPE, 2017) If you suspect fabricated data in a submitted manuscript (Wager, 2006a) Ghost, guest, or gift authorship in a submitted manuscript (Wager, 2006b) Undisclosed conflict of interest Plagiarism in a submitted manuscript (Wager, 2006c) 34.8 Confirmation Bias, scientific misconduct and the paradox of high-flying academic careers Scientists are human, and humans are fallible

The authors were also financially supported by grants from the National Natural Science Foundation of China [82070432, 82070435, 82270469 and 82370426], and National Health Commission (2022YFC3601302), Beijing, China, and the Shanghai Commissions of Science and Technology [19DZ2340200] and Health (a special grant for leading academics 2022LJ022), Shanghai, China