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The effect on Trxs was also evident in tumor cells where both Trx1 and Trx2 were modified

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The more recent SURMOUNT-5 trial directly compared tirzepatide to semaglutide and found tirzepatide superior , with 20.2% weight loss versus 13.7% for semaglutide at 72 weeks

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13 In a third case, a 50-year-old female patient with obesity and T2DM was started on semaglutide (0.25mg per week x 4 weeks, then 0.5mg per week x 12 weeks, maintained on 1mg per week) and evaluated for changes in adipose tissue depots surrounding the heart and coronary arteries