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Across different organs, protein-bound lysine is methylated to form -N-trimethyllysine in a reaction catalyzed by specific lysine methyltransferases that use S-adenosyl-methionine (derived from methionine) as a methyl donor

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Endomyocardial biopsies from heart or liver transplant patients treated with CsA showed structural distortion, increased fibrosis, and increased collagen levels (66)

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