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After a 48 h observation period, blood was collected by retroorbital puncture and the mice were euthanized by neck dislocation
In addition, tirzepatide affects certain chemicals in the brain which in turn decreases appetite, increases energy expenditure, and prevents ectopic fat deposition (abnormal fat accumulation in body parts that normally contains small amounts of fat)
What TRIUMPH-1 Actually Reported TRIUMPH-1 randomized 2,339 adults with obesity (BMI 30) or overweight with at least one weight-related comorbidity, without diabetes, 1:1:1:1 across three retatrutide doses and placebo
The BMI cutoff was chosen to best assess the primary endpoint (time in range, that is, glycemic control) through several hypothetical mechanisms of semaglutide, while reducing the risk of participants becoming underweight
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