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2016;310(11):E94757
Although in general GLP-1 agonists seem to decrease digoxins Cmax (the highest concentration of digoxin in the blood after dosing) and delay Tmax (time to peak concentration), overall exposure (expressed by area under the curve [AUC]) remains within the therapeutic window
A total of 3127 individuals were included and randomly assigned 3:3:3:4 to receive either 6 mg, 12 mg, or 36 mg of orforglipron or placebo
A first-in-class, oral, brain-penetrant imipridone, dordaviprone combines mitochondrial ClpP hyperactivation with D2R antagonism, dual mechanisms implicated in antitumor activity across glioma models
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