The SELECT trial demonstrated cardiovascular benefit in patients with established heart disease, showing approximately 20% reduction in major adverse cardiovascular events
On top of medication, you get access to the WeightWatchers app with behavioral coaching, food tracking, and support groups
It upregulates genes involved in collagen synthesis (COL1A1, COL3A1, COL5A1), extracellular matrix remodeling (decorin, fibromodulin), and antioxidant defense (superoxide dismutase, glutathione peroxidase) while simultaneously suppressing genes associated with inflammation (IL-6, TNF-alpha), fibrinogen production, and tissue destruction (several MMPs)
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The exact mechanisms are complex, but broadly NAD+ injections may counteract NAD+ depletion and support better cellular function, especially in high-demand tissues like the brain and muscles