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Several practical factors may explain fatigue during GLP-1 therapy: Reduced food intake due to appetite suppression can lead to lower energy consumption Gastrointestinal side effects like nausea can be physically draining Adaptation to metabolic changes as your body adjusts to the medication For people with diabetes who take insulin or sulfonylureas (like gliclazide) alongside GLP-1 medications, low blood glucose (hypoglycaemia) may cause fatigue
Antonius L
Biological response of cancer cells to radiation treatment
Marder, K
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Notably, mitochondrial dysfunction is closely linked to NLRP3 inflammasome activationbone marrow-derived macrophages deficient in Lcn2 exhibit reduced mitochondrial damage, accompanied by diminished NLRP3 activation and decreased IL-1 production [126]
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