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Individuals considering NAD+ Injections with NMN and 5-Amino-1MQ should first undergo a medical evaluation to determine whether the protocol aligns with their health goals
All current evidence comes from preclinical animal and cellular studies, meaning its efficacy and safety in people remain unproven
The AAFPs evidence-based clinical review states directly: Oral administration of high-dose vitamin B12 (1 to 2 mg daily) is as effective as intramuscular administration for correcting anemia and neurologic symptoms in patients with B12 deficiency (Langan RC, Goodbred AJ, American Family Physician, 2017)
Later work examined NNMT inhibition combined with dietary changes in obese mice, reporting reductions in body weight, fat mass, and hepatic fat, alongside shifts in gut bacterial populations
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