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On the other hand, increased levels of isocitrate and a tendency for high levels of citrate after dendriplex direct exposure may indicate a decreased flux into TCA cycle, with increased accumulation of these metabolites in the extracellular milieu

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In this study, the crystal structure of the GLP-1R ECD/Fab 3F52 complex showed that Trp 33 is a key residue at the Fab-receptor interface

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