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However, the clinical development of some ultra-potent DNA-intercalators like the pyrrolobenzodiazepine (PBD) dimers has been challenged by significant off-target toxicities, potentially related to their persistent DNA damage and the bystander effect [47]

Yet, only some real-world studies have assessed outcomes of semaglutide use over more than six months, limiting its clinical use

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Conversely, others choose morning administration to monitor for adverse effects during waking hours when they can implement management strategies