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It plays an important role in the development of male secondary sex characteristics, sperm production, muscle mass, bone density, fat distribution, and sex drive
Most side effects are dose-dependent
Over-suppression of appetite may lead to nutrient deficiencies if diet quality is poor
The key role of histone acetylation in mGlu2 receptor regulation is also strengthened by the findings that chronic treatment with atypical antipsychotics down-regulates the expression of mGlu2 receptors in the mouse and human prefrontal cortex by increasing the binding of HDAC2 to the Grm2 promoter [39]
Small frequent meals, adequate fats, proper hydration all contribute to better outcomes
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