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DEFENSE AGAINST ELECTROPHILES AND PROTEIN GLUTATHIONYLATION In addition to the defense against oxidants and ROS, GSH plays also an important role in the protection against electrophiles by glutathione- S -transferases (GSTs)
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In parallel, hyperglycemia-induced oxidative stress activates multiple pathological signaling cascades, including PKC, which further disrupt endothelial function and precipitate abnormal blood flow, vascular leakage, and neovascularization, hallmarks of DR (102104)
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