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When NAPQI levels are higher than the livers capacity to neutralize, NAPQI will form protein adducts on the mitochondria of liver cells
Copper complexes, such as the Hinokitiol copper complex, inhibit the deubiquitinase activity of certain proteasomes, contributing to ATF4-associated ER stress and subsequently to paraptosis [147]
Unlike injections, topicals provide a more targeted application, as they can be used directly on the skin and scalp surfaces
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