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EFFC is recognized by reddish-brown patches, usually on the cheeks and ears
The systematic review did not show significant increases in Fournier gangrene or amputation despite early reports
The use of HQ and TC can promote adverse effects, such as allergic and irritative contact dermatitis, confetti-like leukoderma, redness, and telangiectasias
Side effects like reactions at the injection site are common
Any references to age-related changes or tissue-associated signaling are provided only as research context and do not imply human or animal use
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