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P450 reducing equivalents arise either from NADH via cytochrome b5 or from NADPH via cytochrome P450 reductase, both of which are associated with cytochrome P450 in the membrane-localized complexes

The largest reductions were reported in a liraglutide study, although the authors noted substantial interstudy variability and cautioned against overinterpreting agent-specific differences

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If needed, further dose increases can be made in 2.5 mg steps after at least four weeks on the current dose