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In a study of BYETTA in subjects with end-stage renal disease receiving dialysis, mean exenatide exposure increased by 3.4-fold compared to that of subjects with normal renal function [see Use in Specific Populations (8.6)]

A randomized, phase 3, open-label trial comparing the effect of the addition of tirzepatide once weekly versus insulin lispro (U100) three times daily in participants with type 2 diabetes inadequately controlled on insulin glargine (U100) with or without metformin (SURPASS-6)

And then from there, and of course, that will lead to some fat loss as well

Ischemic heart disease including myocardial infarction and chronic ischemia could potentially benefit from the peptide's cardioprotective effects, enhanced coronary angiogenesis, and anti-arrhythmic properties demonstrated in animal models

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