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Visceral fat is metabolically active in ways that promote inflammation and insulin resistance, both of which have downstream effects on hormonal balance

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Although the GLP-1R agonists are used to treat type 2 diabetes in clinic (52, 53), there are direct evidences about the therapeutic actions of GLP-1-based therapies in different healthy conditions in humans, including adipogenesis, osteogenesis, and nociception, with many signaling pathways are involved (54)

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from 8.2% to ~6.5%), outperforming comparators