In the event of an overdose, it is reasonable to employ the usual supportive measures, e.g., remove unabsorbed material from the gastrointestinal tract, employ clinical monitoring (including obtaining an electrocardiogram), and institute supportive therapy as indicated by the patient's clinical status
GLP-1 receptor agonists work by targeting GLP-1 receptors: increasing insulin, decreasing glucagon and delaying gastric emptying 2
When to escalate If you have consistently implemented this entire protocol for 3-4 weeks and still experience fewer than 3 bowel movements per week with significant discomfort, it is time to involve your healthcare provider
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Tirzepatide is administered as a once-weekly subcutaneous injection, with doses typically starting at 2.5 mg and gradually increasing by 2.5 mg every 4 weeks as tolerated to a maintenance dose ranging from 5 mg to 15 mg, depending on individual response and tolerability