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This binding affinity sits in a pharmacologically useful range: strong enough to prevent free copper toxicity, weak enough to release copper at target tissues where local pH drops or competing ligands exist
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Global, regional, and national burden of multiple sclerosis 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016
What has human clinical evidence: ARA-290 produced measurable nerve fiber regrowth in humans with small fiber neuropathy in placebo-controlled trials over 28 days
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