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While translational gaps persist, particularly in dosing, timing, and patient stratification, emerging strategies including mitochondria-targeted antioxidants, nanotherapeutics, and biomarker-guided interventions hold promise for restoring redox homeostasis and improving clinical outcomes

Orally administered glutathione is primarily absorbed in the intestine, while circulating glutathione is cleared by the kidneys, which leads to its poor absorption from the gastrointestinal tract

Reiss RE, Kuwabara T, Smith ML, Gahl WA (1988) Successful pregnancy despite placental cystine crystals in a woman with nephropathic cystinosis

2012 Oct;16(5):E173-7

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