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These compounds can easily enter into redox cycling, generating radical oxygen species, which are the underlying mechanism of MDMA neurotoxicity
Oct 2011;25(7):1333-1341
Additionally, the forebrain lateral septum (LS) appears to mediate the non-avoidant food intake reducing effects of GLP-1Rs in that direct exenatide injection into the rat LS suppresses chow intake but does not enhance kaolin intake ( Finally, very few DVC neurons (~6-12%) are responsive to both aversive and satiating cells, indicating that there are indeed separate nausea and satiety effects by GLP-1R agonism
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