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Additionally, the authors also propose that L-Arginine and Vitamin C also play a role in reducing ROS levels as they have been able to reduce ROS when combined to glucagon-like peptide 1 agonists in diabetic patients

One possibility is that oxidized glutathione directly oxidizes roGFP2 and other reduced proteins, however previous studies (Mller et al., 2017) and the current in vitro and yeast data show that direct roGFP2 oxidation by glutathione is very inefficient

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Pediatric use presents additional considerations given developing systems