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Some of the discrepancies with earlier mouse studies can be accounted for by different adaptations made by T cells based on their surrounding environment, which differs enormously based on whether the T cells are activated in vitro versus in vivo ( Interestingly, the cellular energy sensor AMP-activated protein kinase (AMPK), a known driver of oxidative metabolism and mediator of FAO, has also been implicated in promoting Th1 versus Th2 differentiation
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