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This is not unheard of, as drugs like pioglitazone and acipimox both reduce metabolic complications without treating obesity at all
Dose escalation is occasionally used in longer protocols (8+ weeks) where initial high-dose loading aims to saturate tissue receptors, followed by lower maintenance doses to sustain gene expression changes
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Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model Annals of Clinical and Laboratory Science, 2015 Summer, Volume 45 (Issue 4), Pages 426-32
[1] It is prepared in a 30 mL multi-dose vial with a preservative (2 % benzyl alcohol) for multiple withdrawals
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