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Moreover, existing studies mostly focus on the regulation of RA synovial cells (such as FLS) or macrophages by the cGAS-STING pathway, whereas this study, for the first time, clearly demonstrates the central role of the cGAS-STING-ferroptosis axis in RA chondrocytes, and reveals that GLP-1RAs exerted therapeutic effects on RA through a dual mechanism of directly inhibiting this axis and simultaneously promoting the M2 polarization of macrophages
Among these, compound 2 (Figure 3) demonstrated the strongest inhibitory activity, with an IC 50 value of 6.57 M (94)
The medication slows gastric emptying
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