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Redox Signal 37 , 956971 (2022)
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I went back to the data, and the honest answer is more reassuring, and more practical, than either the fear or the hype suggests
MR is strongly recommended as a means of prioritizing drug targets for cardiovascular research, to avoid expensive failures in phase III randomized controlled trials (RCTs) [18, 19] and to identify mechanistic targets of intervention, complementary to RCTs [19]
Tirzepatide has already gained FDA approval for type 2 diabetes and obesity, while achieving greater weight loss than Novo Nordisks semaglutide in trials
Similar patterns are expected with tirzepatide and retatrutide, though long-term discontinuation data for retatrutide is not yet available
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