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Overexcitation of NMDA R by excessive glutamate release or impaired synaptic clearance leads to the death of neurons by excitotoxicity (70)

250 These mice exhibit impaired axonal mitochondrial membrane potential and bioenergetic function, indicating a lack of reserve capacity

A total of 46 healthy female individuals aged 4569 years were enrolled and divided into the placebo group ( n = 23) or treatment group ( n = 23), which ingested one capsule of 500 mg of hydrolyzed fish cartilage, once a day, every night for 90 days

Toxicological sciences : an official journal of the Society of Toxicology , 147 (2), 466-474