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Phase-2 trials did report some benefits of ipamorelin in the condition, but the results were not deemed clinically significant within 7-10 days of therapy, leading to discontinuation of trials [9, 10]

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It is possible that these non-MAPK pathway-activating mutations do not result in a clinically detectable melanocytic tumor, but when the mutated melanocyte subsequently acquires a tumor-initiating MAPK pathway activating mutation, a clinically detectable tumor develops