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Adv Cancer Res 2014
Remarkably, ER-, but not ER-specific ligands, lead to increased phosphorylation of ERK 1/2, which initiates cell cycle entry (demonstrated by the up-regulation of mitotic markers such as CDK1/cdc2 and PCNA), DNA replication, and duplication of the centrosome -the major microtubule-organizing center in the cell- in dividing cells (Wang et al., 2008)
The assessment involves evaluating cortisol levels at different times, typically 8 AM and 4 PM, to capture diurnal variation
Think of it as the "glue" or the scaffolding that holds everything together
These findings were further confirmed by immunohistochemical analysis (55)
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