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doi: 10.1111/dom.12861 90 SimonMCStrassburgerKNowotnyBKolbHNowotnyPBurkartVet al

Challenges include metabolic heterogeneity across patient populations, off-target effects of systemic metabolic modulators, and a lack of reliable biomarkers to monitor metabolic changes in vivo

The changed electrophoretic isoenzyme pattern may be a sign of a shift in the rate of protein production brought on by ROS-induced DNA damage, which would affect the fractional activities of the proteins [61]

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In another study, DCA administration rescued locomotor deficits and elevated PDH activity in mice with ME/CFS-like manifestations induced by a 25-day repeated forced swimming test [145]