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[1] Furthermore, the dose escalation schedule for Wegovystarting at 0.25 mg weekly and gradually increasing to the maintenance dose of 2.4 mgis designed to improve tolerability, but each dose increase can temporarily intensify side effects, as noted in the SmPC

Treatment was well-tolerated with no severe adverse events

A review of its impact on cardiovascular, diabetic, renal, neuroprotective, and hepatic outcomes

Pre-clinical data suggests upregulation of nerve growth factor and vascular endothelial growth factor in injury models [9]

This schedule draws from practitioner protocols, community experience, and the general principles of GLP-1 receptor agonist titration established in clinical trials