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B6.Cg-Tg(Tek-cre)1Ywa/J ( Tie2 -Cre), B6.SJL-Tg( Vil1 -Cre)997Gum/J ( Vil -Cre), and B6.SJL-Ptprc a Pepc b /BoyJ mice (for bone marrow transplant) were obtained from The Jackson Laboratory
Cytosolic and nuclear NAD + are often considered a shared pool as NAD + diffuses through nuclear pores 58 , and importantly, the concentrations of NAD + in the cytosol, nucleus, and mitochondria mirror the K m of NAD + -consuming enzymes localized to the corresponding compartment, hence these enzymes are sensitive to compartmental fluctuations in NAD + levels 77
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