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In rodents, FGF21-stimulated energy expenditure is mediated via sympathomimetic stimulatory effects on adipose tissue thermogenesis through direct FGF21 central action to achieve negative energy balance [37]

For the OATP1B1 and OATP1B3 inhibition experiments, after the cells were washed twice with TB and incubated with TB for 5 min, 50 L of the pre-dosing solution of the compounds or inhibitors at different concentrations were added into each assigned well for a 30-min incubation

A new meta-analysis shows that GLP-1 medications, such as Ozempic, Wegovy, and Mounjaro, can help significantly reduce blood pressure

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